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General Pathology and Microbiology |
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General and Dental Pharmacology and Therapeutics |
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Dental Materials |
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Pre Clinical Conservative Dentistry |
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Pre
Clinical Prosthodontics, Crown and Bridge |
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General Pathology and
Microbiology |
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Paper No. –I : General Pathology and
Microbiology |
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Teaching Scheme |
Examination Scheme |
Total Marks |
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Hours Per year |
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Lectures |
Practicals |
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120 |
105 |
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225 Hrs |
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Theory Marks |
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Final |
Viva Voce |
Internal |
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70 |
20 |
10 |
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100 |
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Practical Marks |
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Final |
Internal |
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90 |
10 |
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100 |
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200 |
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GENERAL PATHOLOGY
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AIM: |
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At the end of the course the
student should be competent to: |
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Apply the scientific study of
disease processes, which result in morphological
and functional alterations in cells, tissues and
organs to the study of pathology and the
practice of dentistry. |
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OBJECTIVES : |
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Enabling the student |
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1. |
To demonstrate and apply
basic facts, concepts and theories in the field
of Pathology. |
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2. |
To recognize and analyze
pathological changes at macroscopically and
microscopical levels and explain their
observations in terms of disease processes. |
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3. |
To Integrate knowledge from
the basic sciences, clinical medicine and
dentistry in the study of Pathology. |
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4. |
To demonstrate understanding
of the capabilities and limitations of
morphological Pathology in its contribution to
medicine, dentistry and biological research. |
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5. |
To demonstrate ability to
consult resource materials outside lectures,
laboratory and tutorial classes. |
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COURSE CONTENT |
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A. |
General Pathology – |
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1. |
Introduction to Pathology |
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Terminologies |
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The cell in health |
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The normal cell structure |
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The cellular functions |
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2. |
Etiology and Pathogenesis of Disease |
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Cell Injury |
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Types – Congenital |
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Acquired |
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Mainly Acquired causes of disease |
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(Hypoxic injury, chemical injury, physical
injury, immunological injury) |
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3. |
Degenerations |
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Amyloidosis |
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Fatty change |
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Cloudy swelling |
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Hyaline change, mucoid degeneration |
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4. |
Cell death & Necrosis |
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Apoptasis |
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Def, causes, features and types of necrosis |
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Gangrene - Dry, wet, gas |
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Pathological Calcifications |
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(Dystrophic and metastatic) |
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5. |
Inflammation |
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Definition, causes types, and features |
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Acute inflammation |
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a. |
The vascular response |
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b. |
The cellular response |
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c. |
Chemical mediators |
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d. |
The inflammatory cells |
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e. |
Fate |
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Chronic inflammation |
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Granulomations inflammation |
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6. |
Healing |
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Regeneration |
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Repair |
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a. |
Mechanisms |
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b. |
Healing by primary intention |
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c. |
Healing by secondary intention |
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d. |
Fracture healing |
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e. |
Factors influencing healing process |
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f. |
Complications |
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7. |
Tuberculosis |
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Epidemiology |
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Pathogenesis ( Formation of tubercle) |
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Pathological features of Primary and secondary
TB |
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Complications and Fate |
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8. |
Syphilis |
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Epidemiology |
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Types and stages of syphilis |
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Pathological features |
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Diagnostic criterias |
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Oral lesions |
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9. |
Typhoid |
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Epidemiology |
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Pathogenesis (Formation of tuberecle |
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Pathological features |
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Diagnostic criterias |
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10. |
Thrombosis |
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Definition, Pathophysiology |
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Formation, complications & Fate of a thrombus |
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11. |
Embolism |
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Definition |
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Types |
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Effects |
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12. |
Ischaemia and Infraction |
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Definition, etiology, types |
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Infraction of various organs |
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13. |
Derangements of body fluids |
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Oedema – pathogenesis |
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Different types |
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14. |
Disorders of circulation |
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Hyperaemia |
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Shock |
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15. |
Nutritional Disorders |
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Common Vitamin Deficiencies |
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16. |
Immunological mechanisms in disease |
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Humoral & cellular immunity |
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Hypersensitivity & autommunity |
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17. |
AIDS |
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18. |
Hypertension |
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Definition, classification |
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Pathophysiology |
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Effects in various organs |
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19. |
Diabetes Mellitus |
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Def, Classification, Pathogenesis, Pathology in
different organs |
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20. |
Adaptive disorders of growth |
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Atrophy & Hypertrophy, Hyperplasia, Metaplasia
and Dysplasia |
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21. |
General Aspects of neoplesia |
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a. |
Definition, terminology, classification |
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b. |
Differences between benign and malignant
neoplasms |
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c. |
The neoplastic cell |
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d. |
Metastasis |
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e. |
Etiology and pathogenesis of neoplasia,
Carcinogenesis |
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f. |
Tumour biology |
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g. |
Oncogenes and anti-oncogenes |
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h. |
Diagnosis |
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i. |
Precancerous lesions |
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j. |
Common specific
tumours, Sq papilloma & Ca, Basal cell
Ca, Adenoma & Adenoca, Fibroma &
Fibrosarcoma, Lipoma and liposarcoma |
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B. |
Systemic Pathology |
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Anaemias |
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Iron Deficiency anaemia, Megaloblastic anaemia |
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23. |
Leukaemias |
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Acute and chronic leukaemias, Diagnosis and
clinical features |
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24. |
Diseases of Lymph nodes |
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Hodgkin’s disease, Non Hodgkins lymphoma,
Metastatic carcinoma |
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25. |
Diseases of oral cavity |
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Lichen planus, Stomatitis, Leukoplakia, Sq cell
Ca, Dental caries, Dentigerious cyst,
Ameloblastoma |
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26. |
Diseases of salivary glands |
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Normal structure, Sialadenitis, Tumours |
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27. |
Common diseases of Bones |
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Osteomyelitis, Metabolic bone
diseases, Bone Tumours, Osteosarcoma,
Osteocalstoma, Giant cell Tumour, Ewing’s
sarcoma, Fibrous dysplasia, Aneurysmal bone cyst |
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28. |
Diseases of Cardiovascular system |
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Cardiac failuare |
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Congenital heart disease |
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ASD, VSD,PDA Fallot’s Tetrology |
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Infective Endocarditis |
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Atherosclerosis |
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Ischaemic heart Disease |
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29. |
Haemorrhagic Disorders |
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Coagulation cascade |
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Coagulation disorders |
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Platelet funtion |
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Platelet disorders |
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PRACTICALS |
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1. |
Urine |
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Abnormal constitutients |
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Sugar, albumin, ketone bodies |
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2. |
Urine – Abnormal consittuents |
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Blood, bile salts, bile pigments |
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3. |
Haemoglobin (Hb) estimation |
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4. |
Total WBC count |
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5. |
Differential WBC Count |
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6. |
Packed cell volume(PCV,) rythrocyte
sedimentation Rate (ESR) |
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7. |
Bleeding Time & clotting Time |
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8. |
Histopathology |
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Tissue Processing |
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Staining |
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9. |
Histopathology slides |
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Acute appendicitis, Granulation tissue, fatty
liver |
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10. |
Histopathology slides |
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CVC lung, CVC liver, Kidney amyloidosis |
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11. |
Histopathology slides |
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Tuberculosis, Actionomycosis, Rhinosporidiosis |
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12. |
Histopathology slides |
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Papilloma, Basal cell Ca, Sq cell Ca |
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13. |
Histopathology slides |
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Osteosarcoma, osteoclastoma, fibrosarcoma |
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14. |
Histopathology slides |
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Malignant melanoma, Ameloblastoma, Adenoma |
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15. |
Histopathology slides |
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Mixed parotid tumour, metastatic carcinoma in
lymph node |
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LIST OF TEXTBOOKS |
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1. |
Robbins – Pathologic Basis of Disease Cotran,
Kumar, Robbins |
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2. |
Anderson’s Pathology Vol 1 & 2 Editors – Ivan
Damjanov & James Linder |
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3. |
Wintrobe’s clinical Haematolog Lee, Bithell,
Foerster, Athens, Lukens |
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MICROBIOLOGY |
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AIM: |
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To introduce the students to
the exciting world of microbes. To make the
students aware of various branches of
microbiology, importance, significance and
contribution of each branch to mankind and other
fields of medicine. The objectives of teaching
microbiology can be achieved by various teaching
techniques such as : |
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a) |
Lectures |
b) |
Lecture Demonstrations |
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c) |
Practical exercises |
d) |
Audio visual aids |
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e) |
Small group discussions with regular
feed back from the students. |
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OBJECTIVES |
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A. |
Knowledge and Understanding |
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At the end of the Microbiology course the
student is expected to : |
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1. |
Understand the basics of
various branches of microbiology and able to
apply the knowledge relevantly. |
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2. |
Apply the knowledge gained in
related medical subjects like General Medicine
and General Surgery and Dental subjects like
Oral Pathology, Community Dentistry,
Periodontics, Oral Surgery, Pedodontics,
Conservative Dentistry and Oral medicine in
higher classes. |
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3. |
Understand and practice
various methods of Sterilisation and
disinfection in dental clinics. |
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4. |
Have a sound understanding of
various infectious diseases and lesions in the
oral cavity. |
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B. |
SKILLS |
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1. |
Student should have acquired
the skill to diagnose, differentiate various
oral lesions. |
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2. |
Should be able to select,
collect and transport clinical specimens to the
laboratory. |
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3. |
Should be able to carry out proper aseptic
procedures in the dental clinic. |
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A brief syllabus of Microbiology is given as
follows: |
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A. |
GENERAL MICROBIOLOGY: |
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1. |
History, Introduction, Scope, Aims and
Objectives. |
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2. |
Morphology and Physiology of bacteria. |
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3. |
Detail account of Sterlisation and Disinfection. |
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4. |
Brief account of Culture media and Culture
techniques |
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5. |
Basic knowledge of selection,
collection, transport, processing of clinical
Specimens and identification of bacteria. |
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6. |
Bacterial Genetics and Drug Resistance in
bacteria. |
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B. |
IMMUNOLOGY: |
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1. |
Infection - Definition, Classification, Source,
Mode of transmission and types of Infectious
disease. |
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2. |
Immunity |
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3. |
Structure and functions of Immune system |
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4. |
The Complement System |
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5. |
Antigen |
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6. |
Immunoglobulins - Antibodies
- General structure and the role played in
defense mechanism of the body. |
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7. |
Immune response |
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8. |
Antigen - Antibody reactions - with reference to
clinical utility. |
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9. |
Immuno deficiency disorders -
a brief knowledge of various types of immuno
deficiency disorders - A sound knowledge of
immuno deficiency disorders relevant to
dentistry. |
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10. |
Hypersensitivity reactions |
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11. |
ic knowledge of various types
- sound knowledge of autoimmune disorders of
oral cavity and related structures. |
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12. |
Immunology of Transplantation and Malignancy |
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13. |
Immunehaematology |
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C. |
SYSTEMATIC BACTERIOLOGY: |
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1. |
Pyogenic cocci -
Staphylococcus, Streptococcus, Pneumococcus,
Gonococcus, Meningococcus – brief account of
each coccus - detailed account of mode of
spread, laboratory diagnosis, Chemo therapy and
prevention - Detailed account of Cariogenic
Streptococci. |
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2. |
Corynebacterium diphtheriae -
mode of spread, important clinical feature,
Laboratory diagnosis, Chemotherapy and Active
immunisation. |
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3. |
Mycobacteria - Tuberculosis and Leprosy |
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4. |
Clostridium - Gas gangrene, food poisoning and
tetanus. |
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5. |
Non-sporing Anaerobes - in
brief about classification and morphology, in
detail about dental pathogens - mechanism of
disease production and prevention. |
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6. |
Spirochaetes - Treponema
pallidum - detailed account of Oral Lesions of
syphilis, Borrelia vincentii. |
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7. |
Actinomycetes. |
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D. |
VIROLOGY: |
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1. |
Introduction |
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2. |
General properties,
cultivation, host - virus interaction with
special reference to Interferon. |
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3. |
Brief account of Laboratory
diagnosis, Chemotherapy and immuno prophylaxis
in general. |
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4. |
A few viruses of relevance to dentistry. |
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Herpes Virus |
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Hepatitis B Virus - brief about other types |
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Human Immunodeficiency Virus (HIV) |
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Mumps Virus |
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Brief - Measles and Rubella Virus |
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5. |
Bacteriophage - structure and Significance |
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E. |
MYCOLOGY |
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1. |
Brief Introduction |
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2. |
Candidosis - in detail |
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3. |
Briefly on oral lesions of systemic mycoses. |
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F. |
PARASITOLOGY: |
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1. |
Brief introduction - protozoans and helminths |
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2. |
Brief knowledge about the
mode of transmission and prevention of commonly
seen parasitic infection in the region. |
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RECOMMENDED BOOKS FOR REGULAR READING: |
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1. |
Text book of Microbiology – R.Ananthanarayan &
C.K.Jayaram Paniker. |
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2. |
Medical Microbiology – David Greenwood et al. |
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BOOKS FOR FURTHER READING/REFERENCE. |
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1. |
Microbiology – Prescott, etal. |
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2. |
Microbiology – Bernard D. Davis , et al. |
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3. |
Clinical & Pathogenic Microbiology – Barbara J
Howard, etal. |
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4. |
Mechanisms of Microbial diseases – Moselio
Schaechter, etal. |
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5. |
Immunology an Introduction – Tizard |
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6. |
Immunology 3rd edition – Evan Roitt , etal. |